Developing approaches to aid neuronal regeneration in the context of neurodegenerative diseases of the cortical output circuitry; modulating neuronal function in psychiatric diseases affecting cortical microcircuitry
Real-time systems analysis of signal transduction and genetic networks at the single cell level
Combining optics, protein engineering, chemistry, electrophysiology, simulation, and theory, at the levels of individual molecules, single cells, and whole, genetically modified, organisms.
High resolution dynamic and spatial studies of prokaryotic cellular organization
Immunology, microbiome, and diet.
Quantitative studies of biological self-organization, and the architecture and dynamics of subcellular structures
Theoretical and experimental studies of self-assembly, DNA/chromosome structure, homology recognition, Roles for Mechanical Force Probes Using Single Molecules
Multicolor and time-resolved electron microscopy of cell signaling
Small molecule probes and therapeutics controlling gene expression, epigenetics, and cell states
Uncovering the intrinsic and extrinsic regulators of stem cell function, and revealing how changes in stem cell activity impact tissue regeneration throughout life
