Guanosine tetraphosphate and pentaphosphate, collectively known as (p)ppGpp or magic spot nucleotides, are effectors of the stringent response, a stress response pathway activated during nutrient and energy deprivation.…
Many organisms on earth have evolved an endogenous self-sustained pacemaker, called the circadian clock, to anticipate daily changes in the environment and adapt its physiology. The circadian clock…
The cycle of day and night is one of the most recurrent and predictable environmental change on our planet. Consequently, organisms evolved mechanisms that give them an ability…
Postdoctoral student Chris Shoemaker of the Denic Lab, who previously won a fellowship from the Damon Runyon Cancer Research Foundation, has now won the Pathway to Independence (K99)…
Many of the approved chemotherapy drugs are either collected from natural sources or inspired by molecules existing in nature. Natural products with anticancer activity can be readily identified…
Anders Sejr Hansen To survive, cells must monitor their environments and elicit appropriate and timely responses to external stresses such as nutrient deprivation. In general, cells achieve this…
Erin O'Shea (l) and Brian Zid The central dogma of molecular biology proposes that information flows from DNA to RNA through the process of transcription and from RNA…
Erin O’Shea and Shankar Mukherji Cells are kind of like little people. Just like we have organs like our heart, lungs and brain that are responsible for core…
(l to r) Anna Puszynska, Joseph Piechura, and Erin O'Shea (not shown Joseph Markson) Organisms from humans to bacteria utilize endogenous timing mechanisms called circadian clocks to coordinate…
