The Woo lab draws from the fields of chemical biology, organic synthesis, and mass spectrometry to understand small molecule activity in the proteome. We seek to develop and apply chemical proteomic methods to study the interactions of therapeutics, natural products, and metabolites within the cellular proteome. In parallel, we develop synthetic access to unique chemical scaffolds followed by identification of their protein targets and functional relationship to biological outcome. Studies from the Woo laboratory will have implications in drug discovery, synthetic methods, and new mechanisms by which small molecules influence biological systems.