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Tag: Science

REGULATION OF CYCLIN-CDK ACTIVITY BY INOSITOL PYROPHOSPHATES

Authors Erin K. O'Shea (left) and Recent work by the O’Shea lab offers new insight into metabolic processes.  Cell metabolism engenders many secondary products, metabolites, that play crucial…

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IKΒ KINASE IKKΕ PLAYS CRITICAL ROLE IN ANTIVIRAL INNATE IMMUNITY

Left to right: Authors Benjamin tenOever, Tom Maniatis and Sze-Ling Ng Innate immunity is the first line of defense against infectious microorganisms. When we are infected by flu…

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SWITCHING OFF A CELL CYCLE CHECKPOINT

A model for feedback control of spindle checkpoint activity Feedback control of spindle checkpoint activity. (Left) Prior to metaphase, chromosomes that are incorrectly aligned on the mitotic spindle…

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A NEW FUNCTION AND MECHANISM FOR MICRORNAS

MicroRNAs are small RNAs that bind and repress target mRNAs. The first microRNA was discovered by Victor Ambros and colleagues in Harvard’s Department of Cellular and Developmental Biology,…

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HUMAN EMBRYONIC STEM CELLS CAN REPROGRAM ADULT SOMATIC NUCLEI

Authors Chad Cowan, Doug Melton and Kevin Eggan Most cells in our tissues have a limited ability to become other cell types in the body and therefore are…

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MAMMALIAN SAD KINASES ARE REQUIRED FOR NEURONAL POLARIZATION

A recent study by Kishi et al. shows how research programs can take unexpected directions. The authors wanted to study how small parts of neuronal processes become specialized…

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FAITHFUL CHROMOSOME SEGREGATION

Andrew Murray and Vahan Indjeian Errors in chromosome segregation lead to disease and death. To prevent such errors, sister chromatids are held together with the protein complex cohesin,…

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