Severe microbial infections, such as tuberculosis and MRSA, often require treatment with three (or more) drugs. Multidrug therapies are currently discovered by empirically testing large numbers of potentially…
The neuromuscular junction on the top is from a young adult mouse; that on the bottom from an 2-year old mouse, which is quite old for a mouse.…
(L to R) Beth Weiner, Nancy Kleckner, Alison Grinthal, and Martin Karplus There is widespread current interest in the roles of mechanical forces for basic cellular process. Many…
(L to R) Linda Turner, Rongjing Zhang, and Howard C. Berg When grown on a rich medium on agar, many bacteria elongate, produce more flagella, and swim in…
Antony M. Jose and Craig P. Hunter Distant cells in our body talk to each other to co-ordinate what they do. Typically, one cell sends a signal that…
Authors Liyun Liu and Woody Hastings Dinoflagellates are an unusual group of organisms in many respects, including a large amount of DNA per cell (up to 40x that…
Co-authors and contributors (l to r): Vishal Trivedi, Eva-Maria Frickel, Martha Gorczyca, Jatin M. Vyas, Adam B. Costoreno, Axel Nohturfft and Shao Chong Zhang. Around the turn of…
Development paper MCB authors Josh Sanes and Michael Fox The synapse is the heart of the nervous system, the site at which information is processed and passed between…
Authors (left to right) Eugenie Shieh, Adam Castoreno, Larissa Jarzylo and Axel Nohturfft The ingredients of a human cell include about 100,000 different proteins, 500 kinds of fat,…
Figure 1 Communication between neurons occurs at specialized structures called synapses, where neurotransmitters released by synaptic vesicles activate receptors on the postsynaptic neuron to elicit chemical and electrical…
