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Tag: Nature

CHROMATIN — A ONE-STOP ENGINEERING SOLUTION FOR COMPACTING DNA AND PARAMETERIZING GENE BEHAVIOR

Erin O'Shea, and Felix Lam If stretched end-to-end, the DNA inside a single human cell would measure approximately 2-3 meters. A fiber of this length is physically compacted…

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WHAT’S “UP” WITH MOUSE VISION?

Co-authors (L to R) Yifeng Zhang, Markus Meister, Joshua R. Sanes, In-Jung Kim, and Masahito Yamagata, A mouse is small, close to the ground. Hawks and cats may…

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TECHNICOLOR BRAINS: MAPPING NEURAL CIRCUITS IN “BRAINBOW” MICE

The co-authors (left to right): Ju Lu, Jeff W. Lichtman, Jean Livet, Joshua R. Sanes, Tamily A. Weissman, Ryan W. Draft, Hyuno Kang More than a century ago,…

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GELBART LAB: GENOME ANALYSIS OF TWELVE DROSOPHILA SPECIES

(L to R): Kyl Myrick, Rob Kulathinal, Beverley Matthews, Lynn Crosby, Kenneth Wiley, Bill Gelbart, Jerry Antone, Sian Gramates Susan Russo and AJ Bhutkar On Thursday, November 8,…

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FEMALE AND MALE MICE SEXUAL BEHAVIORS ARE JUST A SNIFF AWAY

Authors Jennings Xu, Catherine Dulac, and Tali Kimchi In rodents, as in most vertebrates, the social and sexual behaviors of males and females clearly differ. For example, female…

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EMBRYONIC STEM CELLS AND CLONED ANIMALS PRODUCED BY CHROMOSOME TRANSFER INTO MOUSE ZYGOTES

L to R: Garrett Birkhoff, Dieter Egli, Jacqueline Rosains and Kevin Eggan Ten years ago, the cloning of Dolly the sheep confirmed that the mamalian egg (oocyte), possesses…

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NEURODEGENERATION IN A PETRI-DISH: AN EMBRYONIC STEM CELL MODEL FOR ALS

Authors (left to right): Francesco DiGiorgio, Monica Carrasco, Tom Maniatis, Michelle Siao, Kevin Eggan Amyotrophic Lateral Sclerosis, also known as ALS or Lou Gehrig’s disease, is a devastating…

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MAMMALIAN EGG PROGENITORS STAY PUT

Co-authors Amy Wagers and Kevin Eggan One of the central dogmas of mammalian reproduction is that females are born with a fixed pool of meiotic germ cells in…

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NEURAL TUBE DEFECTS: INSIGHTS FROM ZEBRAFISH

Zebrafish notochord scatter-labeled with red and green fluorescent proteins Author Brian Ciruna In this week’s Nature, Brian Ciruna, Alex Schier and colleagues reveal how a major cellular signaling…

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