Work spearheaded by post-doctoral fellow Tadasu Nozaki, in the Kleckner laboratory, and recently published in Nature (PDF), uses a powerful new approach to examine pairing of homologous chromosomes…
Tag: Nancy Kleckner
Scott Keeney will Deliver the Paul Doty Lecture on November 30
On Thursday November 30, Scott Keeney of Memorial Sloan Kettering (MSK) Cancer Center and HHMI investigator will deliver the 2023 Paul Doty Lecture. Named for MCB professor Paul…
Kleckner Lab Investigates the Mechanism of Sister Chromatid Separation: How Bridges Between Sisters Ensure Smooth Separation
Researchers from the Kleckner Lab, in collaboration with researchers at CNRS in France and the Chinese Academy of Sciences, have found evidence that microscopic “inter-axis bridges,” which form…
A New View of Mitotic Chromosomes [Kleckner Lab]
Inheritance at the cellular level rests on the fact that one progenitor cell produces two identical daughter cells. The chromosomes are replicated and then, for each chromosome, the…
Pairing Off to Work: Nucleating Gene Silencing by Direct Interactions of Homologous Double-stranded DNA Molecules [Kleckner Lab]
The genomes of most eukaryotic organisms, including humans, contain large amounts of repetitive DNA organized in the form of heterochromatin. As a result, this specialized chromatin state plays…
The Case of the Missing Crossovers [Kleckner Lab]
Sexual reproduction involves the production of male and female gametes (e.g. sperm and egg) each of which carries a single complete set of chromosomes. In most organisms, this…
NANCY KLECKNER HONORED WITH 2016 THOMAS HUNT MORGAN MEDAL
The Genetics Society of America (GSA) has awarded Nancy Kleckner, the Herchel Smith Professor of Molecular Biology in the Department of Molecular and Cellular Biology, the 2016 Thomas…
CHROMOSOMES AS MECHANICAL OBJECTS [KLECKNER LAB]
We have suggested that chromosomes should be viewed as macroscopic mechanical objects whose functions are governed by accumulation, release and redistribution of mechanical stress. We have proposed specifically…
SPATIAL PATTERNING OF MEIOTIC CROSSOVERS: A CENTURY-OLD MYSTERY [KLECKNER LAB]
(l to r) Shunxin Wang, Nancy Kleckner, Liangran Zhang, and Shen Yin Gamete formation for sexual reproduction involves the specialized cellular program of meiosis. As part of this…
LOOK MOM, NO BREAKS! [KLECKNER LAB]
Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage and recombination. The genome-wide synapsis of…
