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O'Shea Lab > Publications

Papers can also be reqested by sending your inquiry to the O'Shea Lab's Administrator Peter Arvidson.

V. Vijayan, R. Zuzow, E.K. O'Shea, Oscillations in supercoiling drive circadian gene expression in cyanobacteria,PNAS,106 (52), 22564-22568 (2009).Harvard Users External Users

Markson, J.S., and E.K. O'Shea. The Molecular Clockwork of a Protein-based Circadian Oscillator, FEBS Letters, 583 (24), 3938-3947 (2009). Harvard Users External Users

H.D. Kim*, T. Shay*, E.K. O’Shea, & A. Regev, Transcriptional Regulatory Circuits: Predicting Numbers from Alphabets, Science, 325(5939), 429-432 (2009). (*equal contribution). Harvard Users External Users

Kim, H.D. and O’Shea, E. K., A quantitative model of transcription factor activated gene expression, Nature Structural Molecular Biology, 15(11), 1192-1198 (2008). Harvard Users External Users

Capaldi, A.P., Kaplan, T., Liu, Y., Habib, N., Regev, A., Friedman, N., and O’Shea, E. K., Structure and Function of a Transcriptional Network Activated by the MAPK Hog1, Nature Genetics, 40(11), 1300-06 (2008). Harvard Users External Users

F.H. Lam, D.J. Steger, & E.K. O'Shea, Chromatin Decouples Promoter Threshold from Dynamic Range, Nature, 453, 246-250 (2008). pdf

Y.-S. Lee, K. Huang, F.A. Quiocho & E.K. O'Shea, Molecular Basis of Cyclin-CDK-CKI Regulation by Reversible Binding of an Inositol Pyrophosphate, Nature Chemical Biology, 4(1), 25-32 (2008). Harvard Users External Users.

K. Huang, I. Ferrin-O'Connell, W. Zhang, G. Leonard, E.K. O'Shea & F. A. Quiocho, Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway, Molecular Cell, 28(4):614-23 (2007).pdf

M.J. Rust, J.S. Markson, W.S. Lane, D.S. Fisher & E.K. O'Shea, Ordered Phosphorylation Governs Oscillation of a Three-Protein Circadian Clock, Science, 318, 809-812 (2007). Abstract Pub Med

D.Wykoff, A. Rizvi, J. Raser, B. Margolin and E. K. O'Shea, Positive feedback regulates switching of phosphate transporters in S. cerevisiae, Molecular Cell 27, 1005-1013 (2007). pdf

Y-S. Lee, S. Mulugu, J. D. York, and E. K. O’Shea, Regulation of a Cyclin/CDK/CDK Inhibitor Complex by Inositol Pyrophosphates, Science, 316, 109-112 (2007). PubMed Full Text

N. Maheshri & E.K. O’Shea, Living with Noisy Genes: How Cells Function Reliably with Inherent Variability in Gene Expression, Annual Review of Biophysics and Biomolecular Structure, 36:413-34 (2007). pdf

A. Belle, E.K. O'Shea, et al, Quantification of protein half-lives in budding yeast proteome, Proc. Natl. Acad. Sci USA, 103, 13004-13009 (2006). PubMed pdf data 1 data 2

A. Bar-Even, J. Paulsson, N. Maheshri, M. Carmi, E. O'Shea, Y. Pilpel, & N. Barkai, Noise in protein expression scales with natural protein abundance, Nature Genetics, 38, 636-643 (2006). PubMed

N. J. Krogan et al., Global Landscape of Protein Complexes in the Yeast Saccharomyces cerevisiae, Nature, 440, 637-643 (2006). PubMed

N. Dephoure, R. Howson, J. Blethrow, K. M. Shokat & E.K. O'Shea, Combining Chemical Genetics and Proteomics to Identify Protein Kinase Substrates, Proc. Natl. Acad. Sci USA 102, 17940-17945 (2005). PubMed pdf

J.M. Raser & E.K. O'Shea, Noise in Gene Expression: Origins, Consequences, and Control, Science 309, 2010-2013 (2005). PubMed Abstract Full text

M.R. Thomas & E.K. O'Shea, An Intracellular Phosphate Buffer Filters Fluctuations in Extracellular Phosphate Levels, Proc. Natl. Acad. Sci USA 102, 9565-9570 (2005). PubMed pdf

R. Howson, W.-K. Huh, S. Ghaemmaghami, J.V. Falvo, K. Bower, A. Belle, N. Dephoure, D.D. Wykoff, J.S. Weissman & E.K. O'Shea, Construction, Verification, and Experimental Use of Two Epitope-Tagged Collections of Budding Yeast Strains, Comp. Funct. Genomics 6, 2-16 (2005). pdf

S. Huang & E.K. O'Shea, A Systematic High-Throughput Screen of a Yeast Deletion Collection for Mutants Defective in PHO5 Regulation, Genetics 169, 1859-1871 (2005). PubMed pdf

D.D. Wykoff & E.K. O'Shea, Identification of Sumoylated Proteins by Systematic Immunoprecipitation of the Budding Yeast Proteome, Mol. Cell. Proteomics 4, 73-83 (2005). PubMed pdf

J.S. Weissman & E.K. O'Shea, 2004 Irving Sigal Young Investigator Award, Protein Sci. 13, 3333-3335 (2004). PubMed pdf

R.M. Marion, A. Regev, E. Segal, Y. Barash, D. Koller, N. Friedman & E.K. O'Shea, Sfp1 is a Stress- and Nutrient-Sensitive Regulator of Ribosomal Protein Gene Expression, Proc. Natl. Acad. Sci USA 101, 14315-14322 (2004). PubMed

J.M. Raser & E.K. O'Shea, Control of Stochasticity in Eukaryotic Gene Expression, Science, 304, 1811-1814 (2004). PubMed pdf suppl

D.J. Steger & E.K. O'Shea, Genetic Analysis of Chromatin Remodeling Using Budding Yeast as a Model, Methods Enzymol., 377, 55-60 (2004). PubMed pdf

M. Byrne, N. Miller, M. Springer & E.K. O'Shea, A Distal, High-affinity Binding Site on the Cyclin-CDK Substrate Pho4 Is Important for Its Phosphorylation and Regulation, J. Mol. Biol., 335, 57-70 (2004). PubMed pdf

M. Springer*, D.D. Wykoff*, N. Miller & E.K. O'Shea, Partially Phosphorylated Pho4 Activates Transcription of a Subset of Phosphate-Responsive Genes, PLoS Biol., 1, 261-270 (2003). PubMed

W.-K. Huh*, J.V. Falvo*, L.C. Gerke, A.S. Carroll, R.W. Howson, J.S. Weissman & E.K. O'Shea, Global Analysis of Protein Localization in Budding Yeast, Nature, 425, 686-691 (2003). PubMed pdf

S. Ghaemmaghami, W.-K. Huh, K. Bower, R.W. Howson, A. Belle, N. Dephoure, E.K. O'Shea & J.S. Weissman, Global Analysis of Protein Expression in Yeast, Nature, 425, 737-741 (2003). PubMed pdf

D.J. Steger, E.S. Haswell, A. Miller, S. Wente & E.K. O'Shea, Regulation of Chromatin Remodeling by Inositol Polyphosphates, Science, 299, 114-116 (2003). PubMed pdf suppl

A.S. Carroll & E.K. O’Shea, Pho85 and Signaling Environmental Stress, Trends Biochem. Sci., 27, 87-93 (2002). PubMed pdf

S.M. O'Rourke, I. Herskowitz & E.K. O'Shea, Yeast Go Whole HOG for the Hyperosmotic Response, Trends in Genetics, 18, 405-412 (2002). PubMed pdf

D.D. Wykoff & E.K. O'Shea, Phosphate transport and sensing in
Saccharomyces cerevisiae, Genetics, 159, 1491-1499 (2002). PubMed

A.S. Carroll, A.C. Bishop, J.L. DeRisi, K. Shokat & E.K. O’Shea, Chemical Inhibition of the Pho85 Cyclin-Dependent Kinase Reveals an Expanded Role in the Environmental Stress Response, Proc. Natl. Acad. Sci. USA 98,12578-12583 (2001). PubMed

A. Komeili & E.K. O'Shea, New Perspectives on Nuclear Transport, Ann. Rev. Genetics, 35, 341-364 (2001). PubMed

S. Huang, D. Jeffery, M. Anthony & E.K. O'Shea, Functional Analysis of the Cyclin-Dependent Kinase Inhibitor Pho81 Identifies a Novel Inhibitory Domain, Mol. Cell. Biol.21, 6695-6705 (2001). PubMed

D.A. Jeffery, M. Springer, D. King & E.K. O'Shea, Multi-Site Phosphorylation of Pho4 by the Cyclin-CDK Complex Pho80-Pho85 is Semi-Processive with Site Preference, J Mol. Biol. 306, 997-1010 (2001). PubMed :: Supplemental Materials

M.E. Lenburg & E.K. O'Shea, Genetic Evidence for a Morphogenetic Function of the Saccharomyces cerevisiae Pho85 Cyclin-Dependent Kinase, Genetics 157, 39-51 (2001). PubMed

E.K. O'Shea & I. Herskowitz, The Ins and Outs of Cell Polarity, Nature Cell Biol. 2, E39-E41 (2000). PubMed

W.-T. Lau, R.W. Howson, P. Malkus, R. Schekman & E.K. O'Shea, Pho86p, an ER Resident Protein in Saccharomyces cerevisiae, is Required for ER Exit of the High Affinity Phosphate Transporter Pho84p, Proc. Natl. Acad. Sci. USA 97, 1107-1112 (2000). PubMed

A. Komeili & E.K. O'Shea, Nuclear Transport and Transcription, Curr. Opin. Cell Biology 12, 355-360 (2000). PubMed

A. Komeili, K.P. Wedaman, E.K. O'Shea & T. Powers, Mechanism of Metabolic Control: TOR Signaling Links Nitrogen Quality to the Activity of the Rtg1p and Rtg3p Transcription Factors, J.Cell Biology 151, 863-878 (2000). PubMed

E.S. Haswell & E.K. O’Shea, An In Vitro System Recapitulates Chromatin Remodeling at the S. cerevisiae PHO5 Promoter, Mol. Cell. Biol.19, 2817-2827 (1999). PubMed

A. Komeili & E.K. O'Shea, Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4, Science 284, 977-980 (1999). PubMed

A. Kaffman & E.K. O'Shea, Regulation of Nuclear Localization: A Key to a Door, Ann. Rev. Cell Biol. 15, 291-339 (1999). PubMed

A. Kaffman, N.M. Rank & E.K. O’Shea, Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121, Genes & Dev., 12, 2673-2683 (1998). PubMed

A. Kaffman, N.M. Rank, E.M. O’Neill, L. Huang & E.K. O’Shea, The Receptor Msn5 Exports the Phosphorylated Transcription Factor Pho4 Out of the Nucleus, Nature 396, 482-486 (1998). PubMed

W.-T. Lau, K.R. Schneider & E.K. O’Shea, A genetic study of signaling processes for repression of PHO5 transcription in S. cerevisiae, Genetics 150, 1349-1359 (1998). PubMed

E.S. Haswell & E.K. O’Shea, Specificity and Targeting of ATP-Dependent Chromatin Remodeling Machines in Yeast", Cold Spring Harbor Symposium on Quantitative Biology 63, 563-567 (1998). PubMed

E.M. O'Neill, A. Kaffman, E.R. Jolly & E.K. O'Shea, Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex, Science, 271, 209-212 (1996). PubMed

M.E. Lenburg & E.K. O'Shea, Signaling Phosphate Starvation, TIBS 10, 383-387(1996). PubMed

E.M. O'Neill & E.K. O'Shea, Cyclins in initiation, Nature 374, 121-122 (1995). PubMed

A. Kaffman, I. Herskowitz, R. Tjian & E.K. O'Shea, Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85, Science 263, 1153-1156 (1994). PubMed

K.R. Schneider, R.L. Smith & E.K. O'Shea, Phosphate-Regulated Inactivation of the PHO80-PHO85 Kinase by the CDK Inhibitor PHO81, Science 266, 122-126 (1994). PubMed

E.K. O'Shea, K.J. Lumb & P.S. Kim, Peptide Velcro: Design of a Heterodimeric Coiled Coil, Current Biology 3, 658-667 (1993). PubMed

E.K. O'Shea, R. Rutkowski & P.S. Kim, Mechanism of Specificity in the Fos/Jun Oncoprotein Heterodimer, Cell 68, 699-708 (1992). PubMed

R. Rasmussen, D. Benvegnu, E.K. O'Shea, P.S. Kim & T. Alber, X-ray Scattering Indicates that the Leucine Zipper is a Parallel Coiled Coil, Proc. Natl. Acad. Sci. USA 88, 561-564 (1991). PubMed

E.K. O'Shea, J.D. Klemm, P.S. Kim & T. Alber, X-ray Structure of the GCN4 Leucine Zipper, A Two-Stranded, Parallel Coiled Coil, Science 254, 539-544 (1991). PubMed

T.G. Oas, L.P. McIntosh, E.K. O'Shea, F.W. Dahlquist & P.S. Kim, Secondary Structure of a Leucine Zipper Determined by Nuclear Magnetic Resonance Spectroscopy, Biochemistry 29, 2891-2894 (1990). PubMed

J.H. Hu, E.K. O'Shea, P.S. Kim & R.T. Sauer, Sequence Requirements for Coiled-Coils: Analysis With Lambda Repressor-GCN4 Leucine Zipper Fusions, Science 250, 1400-1403 (1990). PubMed

E.K. O'Shea, R. Rutkowski & P.S. Kim, Evidence that the Leucine Zipper is a Coiled Coil, Science 243, 538-542 (1989). PubMed

E.K. O'Shea, R. Rutkowski, W.F. Stafford, III & P.S. Kim, Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun, Science 245, 646-648 (1989). PubMed

 

 

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