O'Shea Lab > People > Aditya Paul> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <SCRIPT SRC="../interact.txt"> </SCRIPT> <link rel="stylesheet" href="../eko_web.css"> </head> <body bgcolor="#FFFFFF" marginwidth="0" marginheight="0" leftmargin="0" topmargin="0" background="../img/i_bk.gif" text="#000000" link="#003366" vlink="#003366" alink="#cc9900" onLoad="load_images('internal'); return true"> <table width="575" border="0" cellspacing="0" cellpadding="0"> <tr> <td> <table width="575" border="0" cellspacing="0" cellpadding="0"> <tr> <td width="411" valign="bottom" align="left" bgcolor="#666666"><img src="../img/i_people_r02_c1.gif" width="411" height="62" alt="o'shea lab projects"></td> <td><img src="../img/i_people_r01_c7.gif" width="164" height="109" alt=""></td> </tr> </table> <table width="575" border="0" cellspacing="0" cellpadding="0"> <tr bgcolor="#CC3300"> <td width="90"><a href="../projects/index.html" onMouseOver = "red('on',1); return true" onMouseOut = "red('off',1); 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The PHO pathway in <em>S. cerevisiae</em>, which positively regulates the transcription of many genes involved in increasing the intracellular concentration of inorganic phosphate (P<sub>i</sub>), is activated in low-phosphate growth conditions. It has been shown that in P<sub>i</sub>-rich conditions, depletion of adenine nucleotide in the growth medium stimulates expression of PHO84, a PHO gene that encodes a phosphate plasma-membrane transporter [Gauthier et al. (2008) <em>Mol Microbiol</em> 68:1583-94]. I will determine if this activation is mediated through the well-characterized PHO pathway. If so, I will use genomic methods to investigate the details of this effect. In particular, we are interested in identifying upstream signaling factors responsible for mediating the influence of adenine on PHO activation, and understanding if and how adenine and phosphate cooperate to control PHO activation. </p> <p><br> </p> </td></tr> </table> </td> <td width="1" bgcolor="#000000"><img src="../img/shim.gif" width="1" height="1"></td> </tr> <tr> <td width="1" bgcolor="#000000"><img src="../img/shim.gif" width="1" height="1"></td> <td width="411" bgcolor="#000000"><img src="../img/shim.gif" width="411" height="1"></td> <td width="1" bgcolor="#000000"><img src="../img/shim.gif" width="1" height="1"></td> </tr> </table> <p align="right"><a href="index.html">other people in the lab</a></p> <p> </p>  <p> </p> <p> </p> <p><a href="../projects/index.html">projects</a> :: <a href="index.html">people</a> :: <a href="../publications/index.html">publications</a> :: <a href="../affiliations/index.html">affiliations</a> :: <a href="../fun_stuff/index.html">fun stuff</a><br> <font color="#666666">--------------------------------------------------------------------------</font>--------<br> <a href="../contact/index.html">contact us</a> :: <a href="../extranet/index.html">lab extranet</a> ::<a href="../intranet/index.html"> lab intranet</a> :: <a href="../index.html"><font color="#CC3300">lab homepage</font></a></p> <p> </p> <p>Website questions, problems, or comments? <a href="mailto:falvo @ mcb. harvard. edu">Email the webmaster.</a><br> </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </body> </html>