| Structural Studies of TRP Channels |
|---|
| M. Zimon, J. Baets, M. Auer-Grumbach, J. Berciano, A. Garcia, E. Lopez-Laso, L. Merlini, D. Hilton-Jones, M. McEntagart, A. H. Crosby, N. Barisic, E. Boltshauser, C. E. Shaw, G. Landouré, C. L. Ludlow, R. Gaudet, H. Houlden, M. M. Reilly, K. H. Fischbeck, C. J. Sumner, V. Timmerman, A. Jordanova and P. De Jonghe Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain (2010) published online May 11 doi:10.1093/brain/awq109. PubMed |
| G. Landouré, A.A. Zdebik, T.L. Martinez, B.G. Burnett, H.C. Stanescu,
H. Inada, Y. Shi, A.A Taye, L. Kong, C.H Munns, S.S. Choo,
C.B. Phelps, R. Paudel, H. Houlden, C.L. Ludlow1, M.J. Caterina,
R. Gaudet, R. Kleta, K.H. Fischbeck and C.J. Sumner Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nature Genetics (2010) 42: 170-4. PubMed 3JXI 3JXJ |
| C.B. Phelps, R.R. Wang, S.S. Choo and R. Gaudet Differential regulation of TRPV1, TRPV3 AND TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.  J. Biol. Chem. (2010) 285: 731-40. PubMed |
| R. Gaudet Divide and conquer: high resolution structural information on TRP channel fragments. J Gen Physiol. (2009) 133: 231-7. PubMed |
| R. Gaudet A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst. (2008) 4: 372-9. Epub 2008 Mar 26. Review. PubMed |
| R. Gaudet TRP channels entering the structural era. J Physiol. (2008) 586: 3565-75. Epub 2008 Jun 5. Review. PubMed |
| C.B. Phelps, R.J. Huang, P.V.
Lishko, R.R. Wang and R. Gaudet Structural analyses of the Ankyrin Repeat Domain of TRPV6 and related TRPV ion channels. Biochemistry (2008) 47: 2476-2484. PubMed 2RFA |
| C.B. Phelps and R. Gaudet The Role of the N-Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization. Journal of Biological Chemistry (2007) 282: 36474-80. PubMed |
| C.B. Phelps, E. Procko, P.V. Lishko,
R.R. Wang and R. Gaudet Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (2007) 1: 148-51. Epub 2007 Jul 9. PubMed |
| P.V. Lishko, E. Procko, X. Jin,
C.B.
Phelps and R.
Gaudet The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron (2007) 54: 905-918. PubMed 2PNN 2NYJ |
| X. Jin, J. Touhey and R. Gaudet
Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J. Biol. Chem. (2006) 281: 25006-10. PubMed 2ETA 2ETB 2ETC |
| Structural Studies of TAP & Antigen Presentation |
| E. Procko and R. Gaudet Antigen processing and presentation: TAPping into ABC transporters. Curr Opin Immunol. (2009) 21: 84-91. Epub 2009 Mar 2.PubMed |
| E. Procko, M.L. O'Mara, W.F. Bennett, D.P. Tieleman and R. Gaudet The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter. FASEB Journal. (2009) 23: 1287-302. Epub 2009 Jan 27.Pubmed |
| R. Gaudet The ABCs of trans(porter) inhibition. Nat Chem Biol. (2008) 4: 454-5. PubMed |
| E. Procko and R. Gaudet Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter. Biochemistry. (2008) 47: 5699-708. Epub 2008 May 2. PubMed |
| E. Procko, I. Ferrin-O'Connell, S-.L. Ng and R. Gaudet
Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Mol Cell. (2006) 24: 51-62. PubMed 2IXE 2IXF 2IXG |
| E. Procko, G. Raghuraman, D.C. Wiley, M. Raghavan and R. Gaudet Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. Immunol. Cell. Biol. (2005) 83: 475-482. PubMed |
| S. Misaghi, Z.-Y. J. Sun, P. Stern, R. Gaudet, G. Wagner and H. Ploegh A structural and functional analysis of the human cytomegalovirus US3 protein. J. Virol. (2004) 78: 413-423.PubMed |
| R. Gaudet and D.C. Wiley Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
EMBO J. (2001) 20: 4964-4972. PubMed 1JJ7 |
| B.E. Gewurz, R. Gaudet, D.
Tortorella, E.W. Wang and
H.L. Ploegh Virus subversion of immunity: a structural perspective. Curr. Opin. Immunol. (2001) 13: 442-450. PubMed |
| B.E. Gewurz, R. Gaudet, D.
Tortorella, E.W. Wang, H.L. Ploegh and D.C. Wiley Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc. Natl Acad. Sci. USA (2001) 98: 6794-6799. PubMed 1IM3 |
| Tip Link Cadherins in Hearing and Deafness |
| M. Sotomayor, W.A. Weihofen, R. Gaudet and D.P. Corey Structural Determinants of Cadherin-23 Function in Hearing and Deafness. Neuron (2010) 66: 85-100. PubMed 2WBX 2WCP 2WHV 2WD0 |
| Ubiquitylation Pathways |
| K. Artavanis-Tsakonas, W.A. Weihofen, J.M. Antos, B.I. Coleman, C.A. Comeaux, M.T. Duraisingh, R. Gaudet and H.L. Ploegh Characterization and structural studies of the Plasmodium falciparum ubiquitin and NEDD8 hydrolase UCHL3. J. Biol. Chem. (2010) 285: 6857-66. PubMed 2WDT 2WE6 |
| C. Schlieker, W.A. Weihofen, E.
Frijns, L.M.
Kattenhorn, R. Gaudet and H.L. Ploegh Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell. (2007) 25: 677-87. PubMed 2J7Q |
| S. Misaghi, P.J. Galardy, W.J.
N.
Meester, H. Ovaa,
H.L. Ploegh and R. Gaudet Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J. Biol. Chem. (2005) 280: 1512-1520. PubMed 1XD3 |
| Phosducin Regulation of G Protein Signaling |
| M. Obin, B.Y. Lee, C. Thulin, G. Meinke, A. Bohm, R.H. Lee, R. Gaudet, J.A. Hopp, V.Y. Arshavsky, B.M. Willardson and A.
Taylor Ubiquitylation of Transducin (T) subunits: Regulation by Phosducin. J. Biol. Chem. (2002) 277: 44566-44575. PubMed |
| R. Gaudet, J.R. Savage, J.N.
McLaughlin, B.M.
Willardson and P.B. Sigler A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G Proteins by phosducin. Mol. Cell (1999) 3: 649-660. PubMed 1B9X 1B9Y |
| A. Bohm, R. Gaudet and P.B.
Sigler
Structural aspects of heterotrimeric G-protein signaling. Curr. Opin. Biotechnol. (1997) 8: 480-487. PubMed |
| R. Gaudet, A. Bohm and P.B.
Sigler
Crystal structure at 2.4 Ĺ resolution of the complex of transducin bg and its regulator, phosducin. Cell (1996) 87: 577-588. PubMed 2TRC |
| Additional Works |
| P.C. Sabeti, P. Varilly, B.
Fry. J.
Lohmueller, E.
Hostetter, C. Costapas, X. Xie, E.H. Byrne, S.A. McCarroll, R.
Gaudet, S.F. Schaffner, E.S. Lander & The International
HapMap
Consortium Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 449, 913-918. PubMed |
| M. Holm, C.S. Hardtke, R. Gaudet and X.-W. Deng
Identification and characterization of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. EMBO J. (2001) 20: 118-127. PubMed |
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Last Updated: 4/15/10