Research: Vertebrate Development All higher organisms consist of large number of highly specialized cell types which are organized in precise patterns to generate the adult. The basic body plan is laid down early in life, during embryogenesis. Our goal is to elucidate the cellular and molecular mechanisms which regulate growth, differentiation, and patterning of the vertebrate embryo. In particular, we are exploring the role of cell-to-cell signalling in the coordinate regulation of groups of cells during embryonic development of the mouse and chick.
Selected Publications: Tian H., Jeong J., Harfe B.D., Tabin C.J., McMahon A.P. (2005). Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development. 132: 133-42. Jeong J., McMahon A.P. (2005). Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. 132: 143-54. Basson, M.A., Akbulut, S., Watson-Johnson, J., Simon, R., Carroll, T.J., Shakya, R., Gross, I., Martin, G.R., Lufkin, T., McMahon, A.P., Wilson, P.D., Costantini, F.D., Mason, I.J. and Licht, J.D. (2005) Sprouty1 Is a Critical Regulator of GDNF/RET-Mediated Kidney Induction. Developmental Cell. 8: 229-239. Gray P.A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D.I., Tsung E.F., Cai Z., Alberta J.A., Cheng L.P., Liu Y., Stenman J.M., Valerius M.T., Billings N., Kim H.A., Greenberg M.E., McMahon A.P., Rowitch D.H., Stiles C.D., Ma Q. (2004). Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 306: 2255-7. Harfe B.D., Scherz P.J., Nissim S., Tian H., McMahon A.P., Tabin CJ. (2004). Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 118: 517-28. Scherz P.J., Harfe B.D., McMahon A.P., Tabin C.J. (2004) The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science. 305: 396-9. Jeong, J., Mao, J., Tenzen, T., Kottmann, A.H. and McMahon, A.P. (2004) Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes & Development. 18: 937-951. Long, F., Chung, U.I., Ohba, S., McMahon, J., Kronenberg, H.M. and McMahon, A.P. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 131: 1309-1318. Carroll, T.J. and McMahon, A.P. (2003) Overview: The Molecular Basis of Kidney Development. In: "The Kidney: From Normal Development to Congenital Disease." Vize, P.D., Woolf, A.S., and Bard, J.B.L., eds. Academic Press, Inc., London, p. 343-376. Majumdar, A., Vainio, S., Kispert, A., McMahon, J. and McMahon, A. P. (2003) Wnt11 and c-Ret/GDNF pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 130: 3175-3185. Charron, F., Stein, E., Jeong, J., McMahon, A.P. and Tessier-Lavigne, M. (2003) The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance. Cell 113: 11-23. Chuang, P.-T., Kawcak, T. and McMahon, A. P. (2003) Feedback control of mammalian Hedgehog signaling by the Hedgehog-Binding Protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes & Development 17: 342-347. McMahon, A. P., Ingham, P. W., and Tabin, C. J. (2003) Developmental roles and clinical significance of Hedgehog signaling. Current Topics in Developmental Biology. 53: 1-114. Wijgerde, A., McMahon, J. A., Rule, M. and McMahon, A. P. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitors domains in the presumptive mammalian spinal cord. Genes & Development 16:2849-2864. Yu, J., Carroll, T. J. and McMahon, A. P. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129: 5301-5312. Megason, S. and McMahon, A. P. (2002) A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129: 2087-2098. Hayashi, S. and McMahon, A. P. (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation / inactivation in the mouse. Developmental Biology 244: 305-318. Zhang, X.M., Ramalho-Santos, M. and McMahon, A.P. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by mouse node. Cell 106: 781-792. Ingham, P.W. and McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes & Development 15: 3059-3087. Lewis, P.M., Dunn, M.P., McMahon, J.A., Logan, M., Martin, J.F., St-Jacques, B. and McMahon, A.P. (2001) Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105: 599-612. |
